This investigation quantifies the relation between cardiorespiratory fitness levels and cardiovascular disease (CVD) mortality within strata of other CVD predictors.
Participants included 25,341 male Cooper Clinic patients who underwent a maximal graded exercise test.
CVD death rates were determined for low (least fit one-fifth), moderate (next two-fifths), and high (top two-fifths) cardiorespiratory fitness categories by strata of smoking habit, blood cholesterol level, resting blood pressure, and health status.
There were 226 cardiovascular deaths during 211,996 man-years of follow-up.
For individuals with none of the major CVD predictors (smoking, elevated resting systolic blood pressure, elevated blood cholesterol), there was a strong inverse relation (P=0.001) between fitness level and CVD mortality.
An inverse relation between CVD mortality and fitness level was seen within strata of cholesterol levels and health status.
No evidence of a trend (P=0.60) for decreased mortality was seen across fitness levels for individuals with elevated systolic blood pressure ; however, a strong inverse gradient (P<0.001) was seen across fitness levels for individuals with normal systolic blood pressure.
There was a tendency for association between high levels of fitness and decreased CVD mortality in smokers compared with low and moderately fit smokers (P<0.076). (...)
Mots-clés Pascal : Aptitude physique, Cardiopathie coronaire, Mortalité, Epidémiologie, Facteur risque, Appareil circulatoire pathologie, Homme
Mots-clés Pascal anglais : Physical fitness, Coronary heart disease, Mortality, Epidemiology, Risk factor, Cardiovascular disease, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0366789
Code Inist : 002B12A03. Création : 25/01/1999.