To review information on the benefits of screening with a sensitive thyroid-stimulating hormone (TSH) test for thyroid dysfunction in asymptomatic patients seeking primary care for other reasons.
This paper focuses on whether screening should be aimed at detection of subclinical thyroid dysfunction and whether persons with mildly abnormal TSH levels can benefit.
A MEDLINE search for studies of screening for thyroid dysfunction and of treatment for complications of subclinical thyroid dysfunction.
Studies of screening with thyroid function tests in the general adult population or in patients seen in the general office setting were selected (n=33).
All controlled studies of treatment in patients with subclinical hypothyroidism or subclinical hyperthyroidism were also included (n=23).
The prevalence of overt and subclinical thyroid dysfunction, the evidence for the efficacy of treatment, and the incidence of complications in defined age and sex groups were extracted from each study.
Screening can detect symptomatic but unsuspected overt thyroid dysfunction.
The yield is highest for women older than 50 years of age : In this group, 1 in 71 women screened could benefit from relief of symptoms.
Evidence of the efficacy of treatment for subclinical thyroid dysfunction is inconclusive. (...)
Mots-clés Pascal : Thyroïde, Trouble fonctionnel, Dépistage, Test TSH, Critère sélection, Facteur efficacité, Essai clinique, Complication, Traitement, Recommandation, Homme, Article synthèse, Thyroïde pathologie
Mots-clés Pascal anglais : Thyroid gland, Dysfunction, Medical screening, TSH-Test, Selection criterion, Effectiveness factor, Clinical trial, Complication, Treatment, Recommendation, Human, Review, Thyroid diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0361807
Code Inist : 002B21C01. Création : 25/01/1999.