3,4-Dichloroaniline-haemoglobin adducts in humans : preliminary data on agricultural workers exposed to propanil.
Propanil is one of the major herbicides used on rice-paddies and is thought to produce adverse health effects through the action of its metabolite 3,4-dichloroaniline (3,4-DCA).
The feasibility of monitoring human exposure to propanil on the basis of 3,4-DCA adducts to haemoglobin (Hb) was investigated.
We developed a method based on gas chromatography negative ion chemical ionization-mass spectrometry (NICI-GC-MS) to quantify 3,4-DCA released from human Hb after alkaline hydrolysis of the protein. 3,4-DCA-Hb adducts were identified in agricultural workers exposed to propanil and were detectable even 4 months after the last herbicide application.
Urine samples collected at the same time had no measurable level of 3,4-DCA. 3,4-DCA-Hb adducts might be useful for monitoring human exposure to 3,4-DCA from agricultural sources.
Mots-clés Pascal : Pesticide, Herbicide, Toxicité, Métabolite, Surveillance biologique, Homme, Exposition professionnelle, Médecine travail, Agriculteur, Marqueur biologique, Hémoglobine, Adduit moléculaire, Anilide, Aniline(3-4,dichloro), Propanil
Mots-clés Pascal anglais : Pesticides, Herbicide, Toxicity, Metabolite, Biological monitoring, Human, Occupational exposure, Occupational medicine, Farmer, Biological marker, Hemoglobin, Molecular adduct, Anilide
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0360874
Code Inist : 002B03G. Création : 25/01/1999.