Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension : principal results of the Hypertension Optimal Treatment (HOT) randomised trial.
Despite treatment, there is often a higher incidence of cardiovascular complications in patients with hypertension than in normotensive individuals.
Inadequate reduction of their blood pressure is a likely cause, but the optimum target blood pressure is not known.
The impact of acetylsalicylic acid (aspirin) has never been investigated in patients with hypertension.
We aimed to assess the optimum target diastolic blood pressure and the potential benefit of a low dose of acetylsalycylic acid in the treatment of hypertension.
18 790 patients from 26 countries, aged 50-80 years (mean 61.5 years) with hypertension and diastolic blood pressure between 100 mm Hg and 115 mm Hg (mean 105mm HG were randomly assigned a target diastolic blood pressure. (...) Interpretation : Intensive lowering of blood press in patients with hypertension was associated with a low rate of cardiovascular events.
The HOT study shows the benefits of lowering the diastolic blood pressure down to 82.6 mm Hg.
Acetylsalycylic acid significantly reduced major cardiovascular events with the greatest benefit seen in all myocardial infarction.
There was no effect on the incidence of stroke or fatal bleeds, but non-fatal bleeds waere twice as common.
Mots-clés Pascal : Prévention, Infarctus, Chimiothérapie, Traitement, Essai clinique
Mots-clés Pascal anglais : Prevention, Infarct, Chemotherapy, Treatment, Clinical trial
Notice produite par :
ENSP - Ecole nationale de la santé publique (devenue EHESP)
Cote : 98/06 V
Code Inist : 002B30A11. Création : 25/01/1999.