Molecular markers of acute upper airway inflammation in workers exposed to fuel-oil ash.
Biomarkers in nasal lavage (NL) fluid may be useful in determining the presence and severity of upper airway inflammation.
We studied 18 boilermakers overhauling a large, oil-fired boiler and 11 utility workers who served as controls for 6 wk.
NL was performed before (NL1), during (NL2), and after (NL3) the overhaul.
We measured nasal fluid levels of interleukins 6 (IL-6) and 8 (IL-8), eosinophilic cationic protein (ECP), and myeloperoxidase (MPO) as markers of response to fuel-oil ash exposure.
In boilermakers, MPO was elevated during boiler work versus preboiler work (mean=33.8 versus 22.7 ng/ml, p<0.05), and at the 2-wk postexposure lavage (NL3) it had declined to 24.2 ng/ml (p=0.08).
Mean IL-8 levels increased in boilermakers between NL1 and NL2 (mean=83.8 versus 134.8 pg/ml, p<0.05), then decreased at NL3 (mean=134.8 versus 89.0 pg/ml, p<0.05).
Nasal fluid vanadium increased in boilermakers between NL1 and NL2 (median<1.0 versus 4.7 ppb, respectively, p<0.05), then decreased at NL3 (median, 4.7 versus<1.0 ppb, respectively, p<0.05).
Levels of IL-6 and ECP did not change significantly during the study.
Utility workers showed no significant change in any marker during the study period.
Particulate matter<10 mum (PM10) levels were higher for boilermakers than for utility workers before boiler work (geometric mean (GM)=0.40 versus 0.10 mg/m3, p<0.05).
This difference was more significant during boiler work (GM=0.47 versus 0.13 mg/m3, p<0.001). (...)
Mots-clés Pascal : Inflammation, Voie respiratoire supérieure, Aigu, Lavage, Nez, Exposition professionnelle, Fuel oil, Cendre, Interleukine 6, Interleukine 8, Peroxidase, Peroxidases, Oxidoreductases, Enzyme, Protéine cationique, Eosinophile, Physiopathologie, Médecine travail, Diagnostic, Marqueur, Homme, Vanadium oxyde, Appareil respiratoire pathologie, Cytokine
Mots-clés Pascal anglais : Inflammation, Upper respiratory tract, Acute, Washing, Nose, Occupational exposure, Fuel oil, Ash, Interleukin 6, Interleukin 8, Peroxidase, Peroxidases, Oxidoreductases, Enzyme, Cationic protein, Eosinophil, Pathophysiology, Occupational medicine, Diagnosis, Marker, Human, Vanadium oxide, Respiratory disease, Cytokine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0353149
Code Inist : 002B03L02. Création : 27/11/1998.