A 4-year study of plasma ochratoxin A in a selected population in Tokyo by immunoassay and immunoaffinity column-linked HPLC.
Employing a competitive ELISA (cELISA) based on monoclonal antibody and a novel immunoaffinity-column (IAC) - linked HPLC-fluorometry, ochratoxin A (OTA) levels in the plasma of 184 healthy volunteers (130 males. 54 females) were surveyed in Tokyo during the 4 years from 1992 to 1996.
It was found that 85% of the cases were positive for OTA except 38% in 1994. and an average value in the positives was estimated as 68 pg/ml.
This suggests that the population in Tokyo is exposed to OTA at high frequency. although the level in plasma is far less than that reported in Europe and Canada.
A partial contribution of fermented dietary foodstuffs, coffee and wine is suspected as the source of the OTA observed in the human plasma.
Mots-clés Pascal : Ochratoxine, Mycotoxine, Taux, Homme, Epidémiologie, Plasma sanguin, Sang, Japon, Asie, Milieu urbain, Etude longitudinale, Analyse quantitative, Liquide biologique, Source pollution, Ochratoxine A
Mots-clés Pascal anglais : Ochratoxin, Mycotoxin, Rate, Human, Epidemiology, Blood plasma, Blood, Japan, Asia, Urban environment, Follow up study, Quantitative analysis, Biological fluid, Pollution source
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0351516
Code Inist : 002B03J. Création : 27/11/1998.