Rather than being an exception, non-linearity between dose and response are the rule in biological systems.
It might even be anticipated that at some doses a response opposite to that seen at high doses could be elicited (hormesis).
Such non-linearity with dose has multiple implications for numerous aspects ofbiomedical research on aging and for experimental design.
Moreover, the implications of such non-linearity are such that governmental regulatory activities and other areas of public health administration will be affected to a large extent once hormesis is widely recognized.
The implications with regard to environmental intervention and subsequent regulatory decisions will certainly profoundly affect the political process, as well.
Mots-clés Pascal : Sénescence, Vieillard, Homme, Longévité, Durée vie, Facteur efficacité, Résistance, Stress, Exercice physique, Mode de vie, Gériatrie, Hormèse
Mots-clés Pascal anglais : Senescence, Elderly, Human, Longevity, Lifetime, Effectiveness factor, Resistance, Stress, Physical exercise, Life habit, Geriatrics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0351441
Code Inist : 002B30A01A1. Création : 27/11/1998.