A study was carried out to evaluate : (a) the value of a cumulative exposure estimate (CEE) calculated from limited information on air concentration ; and (b) whether chronic exposure to mixed organic solvents at a shoe manufacturing factory has induced neurobehavioral changes.
The Neurobehavioral Core Test Battery was administered to 40 female workers from a shoe manufacturing factory and 28 housekeepers as referents.
The airborne concentrations of the solvents as a mixture were 0.46-0.71 at the frame making process and 1.83-2.39 at the adhesive process.
Performance was analyzed by three exposure indices : current department, exposure duration, and CEE.
The Santa Ana Dexterity test showed statistically significant differences only in CEE.
In particular, the group with higher exposures had a significantly poorer performance than the reference group, on preferred hand trials.
The results suggested that CEE appeared to be a better indicator of mixed organic solvents exposure, and neurobehavioral changes were associated with CEE over 10 years.
Mots-clés Pascal : Solvant organique, Composé chimique, Toxicité, Exposition professionnelle, Médecine travail, Industrie cuir, Chaussure, Homme, Mélange, Association toxique, Test neuropsychologique, Comportement, Système nerveux pathologie, Dose cumulée, Neurobehavioral Core Test Battery, Santa Ana Dexterity Test
Mots-clés Pascal anglais : Organic solvent, Chemical compound, Toxicity, Occupational exposure, Occupational medicine, Leather industry, Shoe, Human, Mixture, Toxic association, Neuropsychological test, Behavior, Nervous system diseases, Cumulated dose
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0351307
Code Inist : 002A30E. Création : 27/11/1998.