Polypharmacy : correlations with sex, age and drug regimen. A prescription database study.
To analyse the occurrence of multiple drug use (polypharmacy.
PP) in the population and to identify individuals particularly prone to PP.
Data were derived from the Odense Pharmacoepidemiological Database (OPED) and covered all subsidised prescriptions during 1994 presented by inhabitants in the county of Funen (n=466 567).
The number of individuals concurrently using two to four drugs (minor PP) and five or more drugs (major PP) was calculated on a random day in 1994.
Drugs were classified according to the Anatomical Therapeutical Chemical (ATC) classification index.
The main therapeutic class (second level of the ATC code) was used as an indicator for the type of health problem.
A stepwise backwards logistic regression was used to identify predictors of major PP.
Odds ratios were calculated for different drug classes, and the age and sex of all drug users.
On a random days, 8.3% of the population were exposed to minor PP and 1.2% to major PP.
The prevalence of PP increased with age. and from the age of 70 years, two thirds of all drug users were PP users.
Drug use was 50% more prevalent among women than men, but over the age of 70, the sexes did not differ in the prevalence of major PP.
Many different drug combinations were found. and among major PP users (n=5443), two thirds had their own unique drug regimen, different from all other drug users. (...)
Mots-clés Pascal : Prescription médicale, Epidémiologie, Médicament, Homme, Age, Sexe, Association médicamenteuse, Activité biologique, Enquête, Danemark, Europe
Mots-clés Pascal anglais : Medical prescription, Epidemiology, Drug, Human, Age, Sex, Drug combination, Biological activity, Survey, Denmark, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0348080
Code Inist : 002B02A07. Création : 27/11/1998.