Objectives-To determine the underlying causes of death in a large population based register series of patients with multiple sclerosis.
Methods-The Danish Multiple Sclerosis Registry, which contains virtually all diagnosed cases of multiple sclerosis in Denmark who were alive in 1949 plus cases with onset of multiple sclerosis in the period 1949-93, who have been diagnosed and notified by 1 January 1994, was linked with the Danish Registry of Causes of Death, in which ICD codes for causes of death from the death certificate are stored for all Danish citizens.
6068 register cases of multiple sclerosis, who had died in the period 1951-93, were included.
Multiple sclerosis was noted on the death certificate as the underlying cause of death in 55.4% ; cardiac or vascular diseases in 17.6% ; cancers in 8.6% ; respiratory or infectious diseases in 5.1% ; other natural causes in 9.5% ; accident or suicide in 3.8%. The distribution varied with age at death.
Standardised mortality ratios (SMRs) were computed on the basis of the 8142 incident cases, who had onset of multiple sclerosis within the period 1951-93 ; the SMRs for causes of death other than multiple sclerosis were highest for infectious or pulmonary diseases :
Standardised mortality ratios (SMRs) were computed on the basis of the 8142 incident cases, who had onset of multiple sclerosis within the period 1951-93 ;
2.46 (95% confidence interval (95% CI) 2.04-2.94) ;
suicide : 1.62 (95% CI 1.29-2.01) ;
cardiac or vascular diseases : 1.34 (95% CI 1.22-1.48) ;
accidents 1.34 (95% CI 1.02-1.71) ;
and significantly lower than unity for cancers : 0.79 (95% CI 0.70-0. (...)
Mots-clés Pascal : Sclérose en plaque, Danemark, Europe, Mort, Certificat décès, Etiologie, Epidémiologie, Homme, Système nerveux pathologie, Système nerveux central pathologie, Maladie inflammatoire
Mots-clés Pascal anglais : Multiple sclerosis, Denmark, Europe, Death, Death certificate, Etiology, Epidemiology, Human, Nervous system diseases, Central nervous system disease, Inflammatory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0345802
Code Inist : 002B17F. Création : 27/11/1998.