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  1. Effects of smoking, aromatic amines, and chromates on CD4+and CD8+T lymphocytes in male workers.

    Article - En anglais

    To investigate effects of smoking, aromatic amines (AAs), and chromates (CRs) on T lymphocyte subpopulations, we measured CD3+CD4+and CD8+T lymphocytes in the peripheral blood of 33 nonexposed workers, 25 AA-use workers, 27 AA-production workers, and 19 CR workers (all subjects were males).

    The number of CD4+T lymphocytes in smokers of nonexposed workers was significantly larger than that of the nonsmokers ; also, the numbers of CD4+and CD3+T lymphocytes in smokers of each group of AA-production and AA-use workers were significantly larger than those in nonsmokers.

    Numbers of CD4+and CD3+T lymphocytes in nonsmokers of AA-production and CR workers were significantly smaller than those in nonsmokers of nonexposed workers ; the number of CD8+T lymphocytes in nonsmokers of CR workers was significantly smaller than that in nonsmokers of nonexposed workers.

    This cross-sectional study suggests that (1) smoking increases CD4+ (and CD3+) T lymphocytes in all categories of workers except for CR workers ; (2) exposure to CRs and AAs decreases CD4+ (and CD3+) T lymphocytes ; (3) the magnitude of decrease in CD4+T lymphocytes is large among CR workers, intermediate among AA-production workers, and small among AA-use workers regardless of smoking status ; and (4) exposure to CRs also decreases CD8+T lymphocytes.

    Mots-clés Pascal : Tabagisme, Arylamine, Amine, Composé aromatique, Chromate, Toxicité, Homme, Exposition professionnelle, Médecine travail, Lymphocyte T, Sous population cellulaire

    Mots-clés Pascal anglais : Tobacco smoking, Arylamine, Amine, Aromatic compound, Chromates, Toxicity, Human, Occupational exposure, Occupational medicine, T-Lymphocyte, Cell subpopulation

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0344906

    Code Inist : 002B03E. Création : 27/11/1998.