The observation of orthostatic hypotension in an index case of manganese toxicity lead to this prospective attempt to evaluate cardiovascular autonomic function and cognitive and emotional neurotoxicity in eight manganese alloy welders and machinists.
The subjects consisted of a convenience sample consisting of an index case of manganese dementia, his four co-workers in a « frog shop » for gouging, welding, and grinding repair of high manganese railway track and a convenience sample of three mild steel welders with lesser manganese exposure also referred because of cognitive or autonomic symptoms.
Frog shop air manganese samples 9.6-10 years before and 1.2-3.4 years after the diagnosis of the index case exceeded 1.0 mg/m3 in 29% and 0.2 mg/m3 in 62%. Twenty-four-hour electrocardiographic (Holter) monitoring was used to determine the temporal variability of the heartrate (RR'interval) and the rates of change at low frequency (0.04-0.15 Hz) and high frequency (0.15-0.40Hz).
MMPI and MCMI personality assessment and short-term memory, figure copy, controlled oral word association, and symbol digit tests were used.
The five frog shop workers had abnormal sympathovagal balance with decreased high frequency variability (increased In LF/In HF).
Seven of the eight workers had symptoms of autonomic dysfunction and significantly decreased heart rate variability (rMSSD) but these did not distinguish the relative exposure. (...)
Mots-clés Pascal : Manganèse, Métal lourd, Toxicité, Exposition professionnelle, Médecine travail, Homme, Industrie métallurgique, Système nerveux autonome, Trouble rythme cardiaque, Appareil circulatoire pathologie, Hypotension artérielle orthostatique, Enregistrement Holter
Mots-clés Pascal anglais : Manganese, Heavy metal, Toxicity, Occupational exposure, Occupational medicine, Human, Metallurgical industry, Autonomic nervous system, Arrhythmia, Cardiovascular disease, Postural hypotension, Holter recording
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0344905
Code Inist : 002B03L05. Création : 27/11/1998.