The atherosclerotic process begins in childhood but, in general, does not reach the clinical horizon until after the fifth decade of life, at which point the best opportunities for prevention and intervention hive been lost In order to identify children with a high risk of developing coronary artery disease (CAD), risk factors measured in children that are the most informative indicators of future risk must be identified.
Using a novel analytical strategy that incorporates a continuum of information about context dependency, we investigated whether there were significant differences in intermediate biochemical and physiological traits between children (189 females and 188 males, ages 5-20.5 years) with and without a strong family history of clinically-defined CAD at three levels of context dependency (coarse grain, medium grain, and fine grain).
In the coarse-grained analysis we tested for differences in mean levels of nine intermediate traits (lipids, apolipoproteins, blood pressure traits) and indices of external and internal environmental context (age, body mass index, smoking status).
Female children with a strong family history had higher average levels for total cholesterol, triglyceride, Apo B, and systolic blood pressure and were on average older and weighed more than female children with a weak family history of CAD. (...)
Mots-clés Pascal : Athérosclérose, Artère coronaire, Enfant, Homme, Histoire familiale, Facteur risque, Lipide, Apolipoprotéine, Pression sanguine, Hémodynamique, Age, Indice masse corporelle, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Atherosclerosis, Coronary artery, Child, Human, Family story, Risk factor, Lipids, Apolipoproteins, Blood pressure, Hemodynamics, Age, Body mass index, Epidemiology, United States, North America, America, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0343808
Code Inist : 002B12B01. Création : 27/11/1998.