The rate of intrafamilial transmission of the hepatitis C virus (HCV) was investigated in 90 family members of 41 index patients with type C chronic liver disease.
Antibody to HCV (anti-HCV) was detected by the EIA method (Abbott-Axsym Sys) and Hepatitis C virus RNA, by the polymerase chain reaction (Nested PCR).
We also investigated the presence of anti-HCV in 350 healthy persons (control group).
The subjects in the study included 38 spouses. 45 children and others (1 relative and 6 parents).
Four family members including 3/38 (7.8%) spouses and 1 sister were found to be positive for anti HCV antibodies but none had HCV RNA.
Anti-HCV was not detected in the children of index patients.
The prevalence of anti-HCV in the families of index patients was significantly higher than in the controls (4.3% versus 0.85%) (p=0.0355).
We concluded that the intrafamilial transmission of HCV is possible but occurs at a low rate.
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Transmission, Milieu familial, Dissémination, Homme, Prévalence, Virus hépatite C, Hepacivirus, Flaviviridae, Virus, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Transmission, Family environment, Dissemination, Human, Prevalence, Hepatitis C virus, Hepacivirus, Flaviviridae, Virus, Digestive diseases, Hepatic disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0343477
Code Inist : 002B05C02G. Création : 27/11/1998.