We determined the secular trend in blood lead levels in a cohort of 104 children born in Mexico City between 1987 and 1993.
We grouped children by the calendar year in which they reached 6 mo of age and measured blood lead levels every 6 mo until they attained 36 mo of age.
The overall geometric mean blood lead level was 9.6 mug/dl (range=1.5-59.5 mug/dl).
A repeated measures analysis of variance revealed a highly significant linear trend in blood lead level with year (p<. 001) ; there was a maximum decrease of 7.6 mug/dl between 1989 and 1993.
There was a highly significant quadratic age effect (p<. 001) ; blood lead levels rose between 6 and 18 mo of age and decreased thereafter.
There was a marginally significant interaction between age of the child and year.
Family use of lead-glazed pottery significantly elevated blood lead levels (p=028).
The downward trend in blood lead levels during the time period of study corresponded to the reduction in various sources of lead exposure.
Mots-clés Pascal : Plomb, Métal lourd, Polluant, Environnement, Relation temps réponse, Epidémiologie, Taux, Sang, Enfant, Homme, Milieu urbain, Mexique, Amérique Centrale, Amérique, Etude longitudinale, Tendance
Mots-clés Pascal anglais : Lead, Heavy metal, Pollutant, Environment, Time response relation, Epidemiology, Rate, Blood, Child, Human, Urban environment, Mexico, Central America, America, Follow up study, Trend
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0343284
Code Inist : 002B03M01. Création : 27/11/1998.