While the incidence of Clostridium difficile-associated diarrhoea (CDAD) has increased sharply over the last 15 years, its risk factors are still not well defined.
The aim of this study was to review cases of CDAD at the major teaching hospital in Tasmania, Australia, to identify risk factors for CDAD and their association with prognosis.
A retrospective review of the medical records of adult patients admitted to the hospital between January 1994 and December 1996 was performed.
Sixty-four patients who developed CDAD prior to or during their admission, and an additional 120 diarrhoea-free patients (the control group) were studied.
An extensive range of demographic and clinical variables were recorded, and the differences between the control group and patients with CDAD were evaluated.
The CDAD patients had a median age of 66 years (range 22-95 years), with females accounting for 52% of cases.
There were no significant demographic differences from the control group.
Identifiable risk factors for developing CDAD were severe underlying disease, renal impairment, exposure to antibiotics or antineoplastic agents, and the use of total parenteral nutrition or nasogastric feeding.
Cephalosporins were the most frequently used antibiotics in both CDAD and control patients, with cefotaxime being the only antibiotic which was identified as being significantly associated with an increased risk of CDAD. (...)
Mots-clés Pascal : Bactériose, Infection, Clostridium difficile, Clostridiaceae, Clostridiales, Bactérie, Diarrhée, Epidémiologie, Pronostic, Tasmanie, Australie, Océanie, Facteur risque, Homme, Antibiotique, Article synthèse, Appareil digestif pathologie, Intestin pathologie
Mots-clés Pascal anglais : Bacteriosis, Infection, Clostridium difficile, Clostridiaceae, Clostridiales, Bacteria, Diarrhea, Epidemiology, Prognosis, Tasmania, Australia, Oceania, Risk factor, Human, Antibiotic, Review, Digestive diseases, Intestinal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0341248
Code Inist : 002B05B02F. Création : 27/11/1998.