In order to elucidate whether urinary levels of inorganic and organic arsenic metabolites are associated with previous exposure to high-arsenic artesian well water, a total of 302 residents of age 30 yr or older were recruited from three arseniasis-hyperendemic villages in Taiwan.
Most study subjects had stopped consuming high-arsenic artesian well water for more than 20 yr.
The mean total arsenic (Ast) determined by inductively coupled plasma mass spectrometer (ICPMS) was 267.05 ± 20.95 mug/L, and the mean level of inorganic arsenic and its metabolites (Asi) was 86.08 ± 3.43 mug/L. In the multivariate analysis, urinary dimethylarsinic acid (DMA) levels were significantly inversely associated with age, with women exhibiting significantly lower urinary amounts of arsenite [As (III) ], arsenate [As (V) ], monomethylarsonic acid (MMA), organic arsenic (As0), and Ast compared to men.
After adjustment for age and sex, previous cumulative arsenic exposure through consumption of artesian well water was significantly associated with elevated urinary levels of MMA and DMA, but not As (III)+As (V), As0, and Ast.
In the multivariate analysis, the percentage of As0 in As, was significantly higher in men than women, but this was not significantly associated with age.
The percentage of As (III)+As (V) in As, increased significantly with age, while the reverse was noted with DMA in Ast. (...)
Mots-clés Pascal : Toxicologie, Long terme, Arsenic Composé, Arsenic Composé organique, Métabolite, Epidémiologie, Taiwan, Asie, Puits artésien, Homme, Sexe, Age, Liquide biologique, Urine, Coefficient corrélation, Analyse multivariable, Arsinique acide(diméthyl), Arsonique acide(méthyl)
Mots-clés Pascal anglais : Toxicology, Long term, Arsenic Compounds, Arsenic Organic compounds, Metabolite, Epidemiology, Taiwan, Asia, Artesian wells, Human, Sex, Age, Biological fluid, Urine, Correlation coefficient, Multivariate analysis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0340011
Code Inist : 002B03L06. Création : 27/11/1998.