A screening policy has not been well defined in first-degree relatives of patients with sporadic colorectal cancer.
This study estimated the risk of colorectal adenoma in a cohort of individuals with only 1 affected first-degree relative.
A total of 476 first-degree relatives (age, 40-74 years) of 195 patients with sporadic colorectal cancer were offered a colonoscopy.
Each examined relative was matched with 2 controls for age, sex, symptoms, and center.
The prevalence of colorectal adenomas was compared using a multiple logistic regression analysis.
In 185 relatives, odds ratios were 1.5 (95% confidence interval [Cl], 1.0-2.4) for adenomas, 2.5 for large adenomas (95% Cl, 1.1-5.4), 1.2 for small adenomas (95% Cl, 0.7-1.9), and 2.6 (95% Cl, 1.3-5.1) for high-risk adenomas (=1 cm in size and/or with a villous component).
The prevalence of high-risk adenomas in relatives was higher when the index patient was younger than 65 years, was male, and had distal rather than proximal cancer.
Subjects with only 1 affected first-degree relative are at increased risk for developing large adenomas.
Mots-clés Pascal : Carcinome, Côlon, Rectum, Sporadique, Dépistage, Adénome, Colonoscopie, Parent, Epidémiologie, Homme, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Endoscopie
Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Sporadic, Medical screening, Adenoma, Colonoscopy, Parent, Epidemiology, Human, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Endoscopy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0335709
Code Inist : 002B30A01A2. Création : 27/11/1998.