Serum creatinine and endogenous creatinine clearance (CrCl) are widely used measures of renal function.
This study compares the precision, bias, and sources of error in using different CrCl measures to estimate the glomerular filtration rate (GFR) in 118 men and women screened for the African-American Study of Kidney Disease and Hypertension (AASK) pilot study.
We measured serum creatinine, 24-hour CrCl, and CrCl during timed clearance periods conducted simultaneously with an 125I-iothalamate GFR study.
Serum creatinine was measured using two different kinetic rate Jaffe methods (CX3 and Hitachi).
After standardization for body surface area, the different measures of renal function available for each individual were compared with the 125I-iothalamate GFR simultaneous to the CrCl. in a subset of 50 participants, the CrCl measures were compared with a follow-up GFR (fGFR).
The mean 125I-iothalamate GFR was 65.2 (SD, 26.4), with a range of 11 to 122 mL/min/1.73 m2.
The mean ± SD percentage differences from the GFR were - 9% ± 22% for the Cockcroft-Gault estimated CrCl, 1% ± 29% for the 24-hour CrCl, and 8% ± 16% for the CX3 simultaneous CrCl.
The Hitachi method overestimated serum creatinine and underestimated GFR.
Compared with an fGFR, the mean ± SD differences were 2% ± 19% for the first GFR, - 6% ± 20% for the Cockcroft-Gault estimated CrCl, 10% ± 28% for the 24-hour CrCl, and 14% ± 29% for the CX3 simultaneous CrCl. (...)
Mots-clés Pascal : Fonction rénale, Evaluation, Filtration glomérulaire, Exploration radioisotopique, Clairance, Iode composé, Effet biologique, Origine ethnique, Négroïde, Méthodologie, Homme, Appareil urinaire
Mots-clés Pascal anglais : Renal function, Evaluation, Glomerular filtration, Radionuclide study, Clearance, Iodine compounds, Biological effect, Ethnic origin, Negroid, Methodology, Human, Urinary system
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0335320
Code Inist : 002B24I. Création : 27/11/1998.