Primary biliary cirrhosis (PBC) is a liver disease of unknown etiology characterized by chronic nonsuppurative destructive cholangitis (CNSDC) of intrahepatic septal and interlobular bile ducts.
It is generally defined as an autoimmune disease.
Characteristically, patients with PBC have a cholestatic serum hepatic profile and circulating antimitochondrial antibodies (AMA).
PBC is progressive and ultimately leads to biliary cirrhosis and liver failure.
It occurs at least three times more often in women than in men and it is the most common indication for liver transplantation in women around the world.
There is no known cure for PBC.
Despite the remarkable progress elucidating the genetics of breast cancer, and the effort placed on breast cancer education and screening methods, the mortality of breast cancer remains unacceptably high.
In this essay, we describe the similarities between breast cancer and PBC and how their pathogenesis may be related.
The hypothesis stated herein has evolved from reports from the early 1980s that linked an increased risk for breast cancer with PBC, and from the author's clinical experience with patients who suffer from both diseases.
The association between these two diseases in the USA merits further investigation.
If it is confirmed, risk factors involved in their pathogenesis will be identified.
Mots-clés Pascal : Carcinome, Glande mammaire, Association morbide, Cirrhose biliaire, Primitif, Pathogénie, Similitude, Evolution, Perspective, Homme, Femelle, Tumeur maligne, Glande mammaire pathologie, Appareil digestif pathologie, Foie pathologie, Voie biliaire pathologie, Immunopathologie, Maladie autoimmune
Mots-clés Pascal anglais : Carcinoma, Mammary gland, Concomitant disease, Biliary cirrhosis, Primitive, Pathogenesis, Similarity, Evolution, Perspective, Human, Female, Malignant tumor, Mammary gland diseases, Digestive diseases, Hepatic disease, Biliary tract disease, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0334983
Code Inist : 002B13C03. Création : 27/11/1998.