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  1. A randomized, community trial of intensive sexually transmitted disease control for AIDS prevention, Rakai, Uganda.

    Article - En anglais


    To describe the design and first-round survey results of a trial of intensive sexually transmitted disease (STD) control to reduce HIV-1 incidence.

    Study design 

    Randomized, controlled, community-based trial in Rakai District, Uganda.


    In this ongoing study, 56 communities were grouped into 10 clusters designed to encompass social/sexual networks ; clusters within blocks were randomly assigned to the intervention or control arm.

    Every 10 months, all consenting resident adults aged 15-59 years are visited in the home for interview and sample collection (serological sample, urine, and, in the case of women, self-administered vaginal swabs).

    Sera are tested for HIV-1, syphilis, gonorrhea, chlamydia, trichomonas and bacterial vaginosis.

    Following interview, all consenting adults are offered directly observed, single oral dose treatment (STD treatment in the intervention arm, anthelminthic and iron-folate in the control arm).

    Treatment is administered irrespective of symptoms or laboratory testing (mass treatment strategy).

    Both arms receive identical health education, condom and serological counseling services.


    In the first home visit round, the study enrolled 5834 intervention and 5784 control arm subjects.

    Compliance with interview, sample collection and treatment was high in both arms (over 90%). Study arm populations were comparable with respect to sociodemographic and behavioral characteristics, and baseline HIV and STD rates. (...)

    Mots-clés Pascal : Maladie sexuellement transmissible, Lutte sanitaire, Surveillance sanitaire, SIDA, Virose, Infection, Méthode, Incidence, Prévention, Ouganda, Afrique, Homme, Traitement, Prévalence, Dépistage, Programme sanitaire, Immunopathologie, Immunodéficit

    Mots-clés Pascal anglais : Sexually transmitted disease, Sanitary control, Sanitary surveillance, AIDS, Viral disease, Infection, Method, Incidence, Prevention, Uganda, Africa, Human, Treatment, Prevalence, Medical screening, Sanitary program, Immunopathology, Immune deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0331435

    Code Inist : 002B05C02D. Création : 27/11/1998.