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  1. Methicillin-resistant Staphylococcus aureus : Acquisition and risk of death in patients in the intensive care unit.

    Article - En anglais

    Objective 

    To evaluate the risk of patients in intensive care units (ICU) of becoming infected with methicillin-resistant Staphylococcus aureus (MRSA) and to assess the mortality during a six week follow-up period, compared with patients who developed methicillin-sensitive S. aureus (MSSA) infection.

    Design 

    Point prevalence survey.

    Setting 

    1417 ICU in 17 Western European countries.

    Subjects 

    10038 patients in ICU who were part in the EPIC (European Prevalence of Infection in Intensive Care) Study.

    Main outcome measures 

    Prevalence of MRSA and MSSA ICU-acquired infections, risk factors, and mortality.

    Results 

    On the study day 21% of patients had ICU-acquired infections.

    The most commonly reported pathogen was Staphylococcus aureus (30%). Overall, 60% of strains of S. aureus were resistant to methicillin (with a wide intercountry variation).

    The most commonly reported MRSA infections were pneumonia and lower respiratory tract infections.

    The most important risk factor for MRSA was the length of stay in the ICU.

    MRSA infection reduced the chance of survival, particularly when it was found in lower respiratory tract infections : the risk of mortality was three times higher in patients with MRSA than in those with MSSA.

    Conclusion 

    Patients in ICU are at high risk of becoming infected with MRSA.

    The longer they stay, the higher the risk.

    Patients with MRSA infections are less likely to survive than those with MSSA.

    Mots-clés Pascal : Hospitalisation, Unité soin intensif, Complication, Surinfection, Infection nosocomiale, Staphylococcus aureus, Micrococcaceae, Micrococcales, Bactérie, Résistance traitement, Antibactérien, Chimiothérapie, Méticilline, Facteur risque, Mortalité, Etude statistique, Homme, Pénicilline dérivé, Réanimation, Bactériose, Infection

    Mots-clés Pascal anglais : Hospitalization, Intensive care unit, Complication, Superinfection, Nosocomial infection, Staphylococcus aureus, Micrococcaceae, Micrococcales, Bacteria, Negative therapeutic reaction, Antibacterial agent, Chemotherapy, Meticillin, Risk factor, Mortality, Statistical study, Human, Penicillin derivatives, Resuscitation, Bacteriosis, Infection

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0321886

    Code Inist : 002B05B02N. Création : 27/11/1998.