Ambient temperature and mortality from unintentional cocaine overdose.
Context. - Hot weather taxes cardiovascular function and is associated with increased deaths from heart disease.
Cocaine can cause hypertension, tachycardia, coronary vasospasm, arrhythmias, and increased core temperature.
To determine the association between mortality from cocaine overdose and hot weather.
Settlng-New York, NY. from 1990 through Design-Retrospective review of medical examiner cases from 1990 through 1995.
Subjects-All fatal unintentional cocaine overdoses from 1990 through 1992 (n=1382) and all hyperthermia deaths of cocaine users (n=10) were used to identify a maximum daily temperature threshold above which mortality from cocaine intoxication increased.
The study population consisted of all fatal unintentional cocaine overdoses from 1993 through 1995 in=2008) and 4 contemporaneous comparison groups that included fatal unintentional opiate overdoses (n=793), all other fatal unintentional overdoses (n=85), and a subset of homicides (n=4638) and fatalities from motor vehicle crashes (n=815).
Main Outcome Measures
- The number of overdose deaths and the proportion of homicides and traffic fatalities with a positive cocaine toxicology test result on days with a maximum temperature above or below the temperature threshold.
- A threshold temperature of 31.1°C (88°F) was identified, above which the mean daily number of fatal cocaine overdoses increased steadily.
On days with a maximum daily temperature of 31. (...)
Mots-clés Pascal : Cocaïne, Surdosage, Rétrospective, Mortalité, Temps chaud, Facteur risque, Etude comparative, Evaluation, Homme, Toxicologie, Toxicomanie
Mots-clés Pascal anglais : Cocaine, Overdosing, Retrospective, Mortality, Hot weather, Risk factor, Comparative study, Evaluation, Human, Toxicology, Drug addiction
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0321289
Code Inist : 002B03D. Création : 27/11/1998.