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  1. Cytogenetics and the surgeon : an invaluable tool in diagnosis, prognosis and counselling of patients with solid tumours.

    Article - En anglais

    Background Cytogenetic studies have become an important part of tumour characterization.

    In a minority of tumours cytogenetic and/or molecular studies may he of help for diagnosis, selection of treatment protocols and predicting outcome.

    Methods This article reviews the literature on solid tumour translocations and established family cancer syndromes.

    In addition, the potential importance of genetics in management of patients with breast, ovarian and pancreatic carcinoma is reviewed.

    Results and conclusion Cytogenetic analysis of tumours may help confirm the diagnosis when conventional histology demonstrates no evidence of differentiation along a particular tissue pathway.

    For patients with well defined cancer syndromes, cytogenetic and molecular analysis offers the prospect of screening to reduce the risk of malignant disease.

    For many malignancies the underlying genetic anomalies are gradually being elucidated.

    Further studies designed to demonstrate the significance of these findings can only be undertaken if tumour material is collected and stored in optimal conditions for cytogenetic and/or molecular biological studies.

    Mots-clés Pascal : Tumeur solide, Facteur prédictif, Diagnostic, Pronostic, Traitement, Exploration cytologique, Cytogénétique, Chromosome, Classification, Dépistage, Prévention, Article synthèse, Revue bibliographique, Homme, Tumeur maligne, Anatomopathologie, Chirurgie, Biologie moléculaire

    Mots-clés Pascal anglais : Solid tumor, Predictive factor, Diagnosis, Prognosis, Treatment, Cytologic investigation, Cytogenetics, Chromosome, Classification, Medical screening, Prevention, Review, Bibliographic review, Human, Malignant tumor, Pathology, Surgery, Molecular biology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0320252

    Code Inist : 002B04G01. Création : 27/11/1998.