Background Drug-resistant tuberculosis threatens efforts to control the disease.
This report describes the prevalence of resistance to four first-line drugs in 35 countries participating in the World Health Organization-lnternational Union against Tuberculosis and Lung Disease Global Project on Anti-Tuberculosis Drug Resistance Surveillance between 1994 and 1997.
Methods The data are from cross-sectional surveys and surveillance reports.
Participating countries followed guidelines to ensure the use of representative samples, accurate histories of treatment, standardized laboratory methods, and common definitions.
A network of reference laboratories provided quality assurance.
The median number of patients studied in each country or region was 555 (range, 59 to 14,344).
Results Among patients with no prior treatment, a median of 9.9 percent of Mycobacterium tuberculosis strains were resistant to at least one drug (range, 2 to 41 percent) ; resistance to isoniazid (7.3 percent) or streptomycin (6.5 percent) was more common than resistance to rifampin (1.8 percent) or ethambutol (1.0 percent).
The prevalence of primary multidrug resistance was 1.4 percent (range, 0 to 14.4 percent).
Among patients with histories of treatment for one month or less, the prevalence of resistance to any of the four drugs was 36.0 percent (range, 5.3 to 100 percent), and the prevalence of multidrug resistance was 13 percent (range, 0 to 54 percent).
The overall prevalences were 12. (...)
Mots-clés Pascal : Antituberculeux, Résistance traitement, Enquête utilité publique, Etude transversale, Guide pratique, OMS, Prévalence, Homme, Mycobactériose, Bactériose, Infection, Chimiothérapie
Mots-clés Pascal anglais : Antituberculous agent, Negative therapeutic reaction, Inquiry for public prosals, Cross sectional study, Handbook, WHO, Prevalence, Human, Mycobacterial infection, Bacteriosis, Infection, Chemotherapy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0311775
Code Inist : 002B02S07. Création : 27/11/1998.