Recent epidemiologic investigations have suggested an association between increased blood levels of insulin-like growth factor 1 (IGF-1) and increased risk of prostate cancer.
Our goal was to determine whether an association exists between serum levels of IGF-1 and one of its binding proteins, insulin-like growth factor-binding protein 3 (IGFBP-3), and prostate cancer risk.
An immunoradiometric assay was used to quantify IGF-1 levels and IGFBP-3 levels in serum samples as part of a population-based, case-control study in Sweden.
The study population comprised 210 patients with newly diagnosed, untreated prostate cancer and 224 frequency-matched control subjects.
Data were analyzed by use of unconditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
Reported P values are two-sided.
The mean serum IGF-1 level for case patients (158.4 ng/mL) was significantly higher than that for control subjects (147.4 ng/mL) (P=02) ; corresponding mean serum IGFBP-3 levels were not significantly different between case patients (2668 ng/mL) and control subjects (2518 ng/mL) (P=09).
We found a moderately strong and statistically significant (P=04) positive association between serum levels of IGF-1 levels and risk of prostate cancer (OR=1.51 ; 95% CI=1.0-2.26 per 100 ng/mL increment) ; the association was particularly strong for men younger than 70 years of age (OR=2.93 ; 95% CI=1.43-5.97). (...)
Mots-clés Pascal : Tumeur maligne, Prostate, Facteur risque, Epidémiologie, Protéine liaison IGFBP, Facteur croissance IGF1, Etude cas témoin, Suède, Europe, Homme, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie, Facteur croissance, Polypeptide
Mots-clés Pascal anglais : Malignant tumor, Prostate, Risk factor, Epidemiology, Insulin like growth factor binding protein, Insulin like growth factor 1, Case control study, Sweden, Europe, Human, Male genital diseases, Urinary system disease, Prostate disease, Growth factor, Polypeptide
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0311052
Code Inist : 002B14D02. Création : 27/11/1998.