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  1. Juvenile dermatomyositis at diagnosis : Clinical characteristics of 79 children.

    Article - En anglais


    To evaluate demographic and clinical characteristics, duration of time between disease onset (date of first rash and/or weakness), and diagnosis/therapy. as well as socioeconomic status, of children with newly diagnosed juvenile dermatomyositis (JDM).


    Structured telephone interview of families of a cohort of 79 children with JDM : interval between onset of symptoms to diagnosis, median of 3 months (range 0.5-20.0).


    At diagnosis, all the children had rash (100%) and proximal muscle weakness (100%) :

    • 58 (73%) had muscle pain ;

    • 51 (65%) fever ;

    • 35 (44%) dysphagia ;

    • 34 (43%) hoarseness ;

    • 29 (37%) abdominal pain ;

    • 28 (35%) arthritis ;

    • 18 (23%) calcinosis, and 10 (13%) melena.

    Muscle derived enzymes were normal in 10% of the children.

    Of the 43 children who had an electromyogram (EMG), 8 (19%) had normal results.

    Fifty-one children had a muscle biopsy : the results were normal/nondiagnostic in 10 (20%). Median time from disease onset to diagnosis was different between racial groups : Caucasians (n=59) 2.0 months ; for minorities (n=20), 6.5 months. (p=0.0008).

    The median time from disease onset to therapy was : Caucasians, 3.0 months ; minorities, 7.2 months (p=0.002).

    Report of calcinosis was associated with increased time to diagnosis and therapy (p=0.04).

    In the 33 children whose first symptom occurred in June-September, rash preceded or accompanied onset of muscle weakness in 83% (n=27). (...)

    Mots-clés Pascal : Dermatomyosite, Enfant, Homme, Age apparition, Phase initiale, Intervalle temps, Diagnostic, Symptomatologie, Facteur sociodémographique, Traitement, Epidémiologie, Peau pathologie, Tissu conjonctif pathologie, Muscle strié pathologie, Maladie système, Maladie autoimmune, Immunopathologie

    Mots-clés Pascal anglais : Dermatomyositis, Child, Human, Age of onset, Early phase, Time interval, Diagnosis, Symptomatology, Sociodemographic factor, Treatment, Epidemiology, Skin disease, Connective tissue disease, Striated muscle disease, Systemic disease, Autoimmune disease, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0310445

    Code Inist : 002B07. Création : 27/11/1998.