To evaluate demographic and clinical characteristics, duration of time between disease onset (date of first rash and/or weakness), and diagnosis/therapy. as well as socioeconomic status, of children with newly diagnosed juvenile dermatomyositis (JDM).
Structured telephone interview of families of a cohort of 79 children with JDM : interval between onset of symptoms to diagnosis, median of 3 months (range 0.5-20.0).
At diagnosis, all the children had rash (100%) and proximal muscle weakness (100%) :
58 (73%) had muscle pain ;
51 (65%) fever ;
35 (44%) dysphagia ;
34 (43%) hoarseness ;
29 (37%) abdominal pain ;
28 (35%) arthritis ;
18 (23%) calcinosis, and 10 (13%) melena.
Muscle derived enzymes were normal in 10% of the children.
Of the 43 children who had an electromyogram (EMG), 8 (19%) had normal results.
Fifty-one children had a muscle biopsy : the results were normal/nondiagnostic in 10 (20%). Median time from disease onset to diagnosis was different between racial groups : Caucasians (n=59) 2.0 months ; for minorities (n=20), 6.5 months. (p=0.0008).
The median time from disease onset to therapy was : Caucasians, 3.0 months ; minorities, 7.2 months (p=0.002).
Report of calcinosis was associated with increased time to diagnosis and therapy (p=0.04).
In the 33 children whose first symptom occurred in June-September, rash preceded or accompanied onset of muscle weakness in 83% (n=27). (...)
Mots-clés Pascal : Dermatomyosite, Enfant, Homme, Age apparition, Phase initiale, Intervalle temps, Diagnostic, Symptomatologie, Facteur sociodémographique, Traitement, Epidémiologie, Peau pathologie, Tissu conjonctif pathologie, Muscle strié pathologie, Maladie système, Maladie autoimmune, Immunopathologie
Mots-clés Pascal anglais : Dermatomyositis, Child, Human, Age of onset, Early phase, Time interval, Diagnosis, Symptomatology, Sociodemographic factor, Treatment, Epidemiology, Skin disease, Connective tissue disease, Striated muscle disease, Systemic disease, Autoimmune disease, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0310445
Code Inist : 002B07. Création : 27/11/1998.