Prevalence and determinants of anti-lytic and anti-latent antibodies to human herpesvirus-8 among Italian individuals at risk of sexually and parenterally transmitted infections.
Three hundred seventy-nine individuals [137 non-injecting drug using (non-IDU) heterosexuals, 130 homosexual men and 112 IDU] attending the human immunodeficiency virus (HIV) testing program of a sexually transmitted disease (STD) clinic in Rome were studied to estimate the prevalence and to identify the modalities of transmission of human herpesvirus-8 (HHV-8) infection.
Serological analysis was performed by using an immunofluorescence assay able to detect anti-latent and anti-lytic HHV-8 antibodies.
Twelve acquired immunodeficiency syndrome (AIDS) - Kaposi's sarcoma (KS) patients and 94 blood donors were tested as reference population groups.
Anti-lytic antibodies were detected in 185 (48.8%) individuals ; 52 of them (13.7%) also had anti-latent antibodies.
Both anti-lytic and anti-latent antibody prevalence were higher among homosexual men (66.9% and 27.7%, respectively) than among IDU (49.1% and 8.0%, respectively) and non-IDU heterosexuals (31.4% and 5.1%, respectively), and tended to increase with age.
Anti-lytic HHV-8 antibodies were associated with syphilis [odds ratio (OR)=3.81] but not with hepatitis C virus (HCV) seropositivity.
HIV-infected homosexual men were more likely to have HHV-8 antibodies than those who were HIV-negative.
When using anti-latent antibodies the direction of the OR remained the same, although the associations did not often reach statistical significance.
Among AIDS-KS patients, 83.3% had anti-lytic and 66.6% had anti-latent antibodies. (...)
Mots-clés Pascal : Virose, Infection, Herpesvirus hominis, Alphaherpesvirinae, Herpesviridae, Virus, Sérologie, Prévalence, Epidémiologie, Facteur risque, Maladie sexuellement transmissible, Transmission homme homme, Italie, Europe, Homme, Herpesvirus hominis 8
Mots-clés Pascal anglais : Viral disease, Infection, Herpesvirus hominis, Alphaherpesvirinae, Herpesviridae, Virus, Serology, Prevalence, Epidemiology, Risk factor, Sexually transmitted disease, Transmission from man to man, Italy, Europe, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0310278
Code Inist : 002B05C02B. Création : 27/11/1998.