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  1. Prevalence and determinants of anti-lytic and anti-latent antibodies to human herpesvirus-8 among Italian individuals at risk of sexually and parenterally transmitted infections.

    Article - En anglais

    Three hundred seventy-nine individuals [137 non-injecting drug using (non-IDU) heterosexuals, 130 homosexual men and 112 IDU] attending the human immunodeficiency virus (HIV) testing program of a sexually transmitted disease (STD) clinic in Rome were studied to estimate the prevalence and to identify the modalities of transmission of human herpesvirus-8 (HHV-8) infection.

    Serological analysis was performed by using an immunofluorescence assay able to detect anti-latent and anti-lytic HHV-8 antibodies.

    Twelve acquired immunodeficiency syndrome (AIDS) - Kaposi's sarcoma (KS) patients and 94 blood donors were tested as reference population groups.

    Anti-lytic antibodies were detected in 185 (48.8%) individuals ; 52 of them (13.7%) also had anti-latent antibodies.

    Both anti-lytic and anti-latent antibody prevalence were higher among homosexual men (66.9% and 27.7%, respectively) than among IDU (49.1% and 8.0%, respectively) and non-IDU heterosexuals (31.4% and 5.1%, respectively), and tended to increase with age.

    Anti-lytic HHV-8 antibodies were associated with syphilis [odds ratio (OR)=3.81] but not with hepatitis C virus (HCV) seropositivity.

    HIV-infected homosexual men were more likely to have HHV-8 antibodies than those who were HIV-negative.

    When using anti-latent antibodies the direction of the OR remained the same, although the associations did not often reach statistical significance.

    Among AIDS-KS patients, 83.3% had anti-lytic and 66.6% had anti-latent antibodies. (...)

    Mots-clés Pascal : Virose, Infection, Herpesvirus hominis, Alphaherpesvirinae, Herpesviridae, Virus, Sérologie, Prévalence, Epidémiologie, Facteur risque, Maladie sexuellement transmissible, Transmission homme homme, Italie, Europe, Homme, Herpesvirus hominis 8

    Mots-clés Pascal anglais : Viral disease, Infection, Herpesvirus hominis, Alphaherpesvirinae, Herpesviridae, Virus, Serology, Prevalence, Epidemiology, Risk factor, Sexually transmitted disease, Transmission from man to man, Italy, Europe, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0310278

    Code Inist : 002B05C02B. Création : 27/11/1998.