Epidemiological studies of in situ breast cancer are sparse, and the role of reproductive history, an established risk modifier for invasive breast cancer, remains incompletely investigated.
To examine possible associations with parity and age at first birth, we undertook a case-control study nested in a nationwide cohort of Swedish women.
The reproductive history of 1,368 women aged 65 or younger with a diagnosis of carcinoma in situ of the breast were compared with that of 6,837 age-matched controls drawn randomly from a population-based Fertility Registry.
Statistical analyses were performed by conditional logistic regression.
Compared to nulliparous women, ever-parous women were at a reduced risk of carcinoma in situ of the breast.
The risk decreased with number of live births, with the estimated risk reduction in the highest parity group (5+), being of the same magnitude as that reported for invasive breast cancer.
By contrast, a positive association with increasing age at first birth was somewhat less pronounced than that observed previously in the same data set with respect to invasive breast cancer.
Our findings indicate that parity affects the risk of invasive breast cancer and carcinoma in situ similarly, whereas the effect of age at first birth appears to be weaker for the risk of carcinoma in situ.
Mots-clés Pascal : Carcinome, Glande mammaire, Cancer in situ, Facteur risque, Epidémiologie, Parité, Age, Gestation, Reproduction, Suède, Europe, Etude cas témoin, Homme, Tumeur maligne, Glande mammaire pathologie
Mots-clés Pascal anglais : Carcinoma, Mammary gland, Carcinoma in situ, Risk factor, Epidemiology, Parity, Age, Pregnancy, Reproduction, Sweden, Europe, Case control study, Human, Malignant tumor, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0310275
Code Inist : 002B20E02. Création : 27/11/1998.