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  1. Safety and immunogenicity of a combined five-component pertussis-diphtheria-tetanus-inactivated poliomyelitis-Haemophilus b conjugate vaccine administered to infants at two, four and six months of age.

    Article - En anglais

    Safety, immunogenicity and lot consistency of five-component pertussis combination vaccine (CPDT-IPV/PRP-T) in infants were compared to that of whole cell pertussis combination vaccine (DPT-IPV/PRP-T), as were separate and combined injections of CPDT-IPV and PRP-T.

    No significant differences in adverse event rates were observed between lots of CPDT-IPV/PRP-T or between separate or combined injections of CPDT-IPV and PRP-T.

    Minor differences in antibody responses were observed between lots of component pertussis vaccine.

    Higher concentrations of diphtheria and tetanus antitoxins were induced by separate than by combined injection of CPDT-IPV and PRP-T, but no other differences in immunogenicity were observed.

    Adverse reactions were more than twice as frequent after whole cell than after component pertussis vaccines.

    Antibody responses to pertussis toxoid, filamentous hemagglutin and pertactin were significantly greater after component vaccines, while the response to type 3 polio-virus was higher after whole cell vaccine.

    No significant differences were observed for other vaccine components.

    CPDT-IPV/PRP-T was safe and immunogenic in infants.

    Antibody results were similar to those observed in a Swedish field trial that demonstrated CPDT to be 85% effective in preventing clinical pertussis.

    Mots-clés Pascal : Vaccin associé, Poliovirus, Enterovirus, Picornaviridae, Virus, Diphtérie, Bactériose, Infection, Haemophilus influenzae, Pasteurellaceae, Bactérie, Tétanos, Coqueluche, Immunogénicité, Toxicité, Nourrisson, Homme, Canada, Amérique du Nord, Amérique

    Mots-clés Pascal anglais : Mixed vaccine, Poliovirus, Enterovirus, Picornaviridae, Virus, Diphtheria, Bacteriosis, Infection, Haemophilus influenzae, Pasteurellaceae, Bacteria, Tetanus, Whooping cough, Immunogenicity, Toxicity, Infant, Human, Canada, North America, America

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0309846

    Code Inist : 002A05F04. Création : 27/11/1998.