Backround The reliable interpretation of the nasal provocation test in allergy diagnosis requires objective and measurable monitoring parameters for clinical practice.
The clinical usefulness of the nasal provocation test has been limited by scanty knowledge of the specificity and sensitivity of the test and a lack of reference values.
Objective To test and compare three objective monitoring parameters of a nasal provocation test in occupational allergic rhinitis.
To evaluate the magnitude of the nasonasal effects in a unilateral allergen challenge.
Methods The monitoring parameters of the nasal reaction were derived from the minimum cross-sectional area on acoustic rhinometry, the nasal resistance on active anterior rhinomanometry and the amount of nasal secretion measured at 15 min intervals for 60 min.
Twenty-three bovine-allergic dairy and beef cattle farmers and 19 exposed, non-allergic control subjects were challenged first with a control solution and then with the cow allergen.
Results All the three monitoring parameters showed high specificity and sensitivity in finding allergic and non-allergic subjects.
The secretion parameter was found to be slightly superior to the acoustic rhinometry and rhinomanometry parameters.
The side difference in the nasal response between the allergen-challenged and the contralateral diluent-challenged cavity was significant for all the parameters among the allergic subjects. (...)
Mots-clés Pascal : Test provocation, Allergène, Voie intranasale, Rhinite, Allergie, Exposition professionnelle, Animal élevage, Rhinomanométrie, Bovin, Artiodactyla, Ungulata, Mammalia, Vertebrata, Epithélium, Exploration clinique, Homme, ORL pathologie, Nez pathologie, Immunopathologie, Médecine travail, Rhinométrie acoustique, Pneumallergène
Mots-clés Pascal anglais : Provocation test, Allergen, Intranasal administration, Rhinitis, Allergy, Occupational exposure, Farming animal, Rhinomanometry, Bovine, Artiodactyla, Ungulata, Mammalia, Vertebrata, Epithelium, Clinical investigation, Human, ENT disease, Nose disease, Immunopathology, Occupational medicine, Aeroallergen
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0309675
Code Inist : 002B06E04. Création : 27/11/1998.