Exposure-response relationships of occupational inhalative allergens.
Only a few threshold limit values exist at present for allergens in the workplace known to cause bronchial asthma.
This contrasts with the great number of occupational asthma cases observed in industrialized countries.
Recently published studies provide clear evidence for exposure intensity response relationships of occupational allergens of plant, microbiological, animal or man-made origin.
If allergen exposure levels fall short of determined limit values, they are not associated with an increased risk of occupational asthma.
Corresponding data are available for wheat flour (1-2.4 mg/m3), fungal alpha-amylase (0.25 ng/m3), natural rubber latex (0.6 ng/m3), western red cedar (0.4 mg/m3) and rat allergens (0.7 mug/m3).
It is suggested to stipulate legally binding threshold limit values (TLV/TWA) on this basis in order to induce more effective primary preventive measures.
If no reliable data on the health risk of an occupational airborne noxa exist, the lowest reasonably practicable exposure level has to be achieved.
Appropriate secondary preventive measures have to be initiated in all workplaces contaminated with airborne allergens.
Verified exposure-response relationships provide the basis for risk assessment and for targeted interventions to reduce the incidence of occupational asthma also in consideration of cost benefit aspects. (...)
Mots-clés Pascal : Allergène, Exposition professionnelle, Asthme, Allergie, Temps exposition, Produit chimique, Enzyme, Arbre, Latex, Animal familier, Article synthèse, Prévalence, Homme, Médecine travail, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie, Pneumallergène
Mots-clés Pascal anglais : Allergen, Occupational exposure, Asthma, Allergy, Exposure time, Chemical product, Enzyme, Tree, Latex, Pet animal, Review, Prevalence, Human, Occupational medicine, Respiratory disease, Obstructive pulmonary disease, Immunopathology, Aeroallergen
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0309471
Code Inist : 002B06C02. Création : 27/11/1998.