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  1. Clinical characteristics of malignant melanoma.

    Article - En anglais

    Malignant melanoma represents a major public health concern.

    Its incidence is rising throughout the world ; in Europe particularly, 13-21 people/100.000 are affected annually.

    Although the aetiology is multifactorial, excessive UV exposure (UVB 290-320 min.) appears to be one of the most important predisposing agent.

    Genetic predisposition plays also a fundamental role.

    Chromosome 9p has been implicated in familial melanoma via the inhibition of a cyclin-dependent kinase 4 which interferes with cell cycle.

    The early detection and recognition of malignant melanoma is the key for possible cure.

    Technical aids like photography, computer based systems, epiluminescence or biopsy increase the sensitivity of formally trained clinicians.

    Mots-clés Pascal : Mélanome, Facteur risque, Incidence, Europe, Gène suppresseur tumeur, Chromosome C9 anormal, Chromosome anormal, Aberration chromosomique, Gène CDKN2, Protooncogène, Gène onc cellulaire, Cytogénétique, Diagnostic, Epidémiologie, Peau, Tumeur maligne, Peau pathologie, Génétique

    Mots-clés Pascal anglais : Melanoma, Risk factor, Incidence, Europe, Tumor suppressor gene, Abnormal chromosome C9, Abnormal chromosome, Chromosomal aberration, CDKN2 gene, Protooncogene, C-Onc gene, Cytogenetics, Diagnosis, Epidemiology, Skin, Malignant tumor, Skin disease, Genetics

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0309302

    Code Inist : 002B08A. Création : 27/11/1998.