Bovine spongiform encephalopathy (BSE) is believed to be transmitted by the ingestion of proteinaceous agents called prions which accumulate in the brain and spinal cord of infected bovines.
Concern has been expressed about the risks of transmission of BSE to humans through BSE prions discharged to the aquatic environment from rendering plants, abattoirs and landfills.
The disease-related form of the prion protein is relatively resistant to degradation, and infectivity decays rather slowly in the environment.
Levels of disinfection used for drinking water treatment would have little effect.
This paper presents the assumptions which were used to model the risks from a rendering plant disposing of cull cattle carcasses in the catchment of a chalk aquifer which is used for a drinking water abstraction.
The risk assessment approach focused on identifying the hydrogeological and physical barriers which would contribute to preventing BSE infectivity gaining entry to the aquifer.
These barriers included inactivation of BSE agent by the rendering process, removal from the effluent by treatment at the plant, filtration and adsorption in the clay and chalk, and dilution in the ground water.
The importance in environmental risk assessment of the cow-to-man species barrier is considered. (...)
Mots-clés Pascal : Article synthèse, Encéphalopathie spongiforme, Prion, Pouvoir infectant, Analyse risque, Milieu aquatique, Encéphale pathologie, Système nerveux central pathologie, Maladie dégénérative, Eau potable, Bovin, Artiodactyla, Ungulata, Mammalia, Vertebrata
Mots-clés Pascal anglais : Review, Spongiform encephalopathy, Prion, Infectivity, Risk analysis, Aquatic environment, Cerebral disorder, Central nervous system disease, Degenerative disease, Drinking water, Bovine, Artiodactyla, Ungulata, Mammalia, Vertebrata
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0308987
Code Inist : 002B30A02A. Création : 27/11/1998.