Based on genetic variability, structural differences in the glycoprotein IIb/IIIa platelet receptor for adhesive proteins result in individual differences in the thrombogenicity of platelets.

Recent studies suggest a controversial association between a genetic polymorphism of the glycoprotein IIIa gene (PIA2) and the risk of coronary artery disease.

In our study, the prevalence of the PIA2 allele in a group of patients undergoing percutaneous coronary revascularization was 37%, a value significantly higher than in controls [13%, odds ratio (OR)=3.93,95% CI, 1.84 to 8.53] suggesting a significant association between this polymorphism and documented coronary stenosis, which is strongest among<60 years old patients (OR=12.30,95% CI, 2.98 to 70.93).

This polymorphism represents an inherited risk factor for severe cardiovascular disease due to coronary occlusion.