logo BDSP

Base documentaire

  1. Polymorphism of the platelet glycoprotein IIIa gene in patients with coronary stenosis.

    Article - En anglais

    Based on genetic variability, structural differences in the glycoprotein IIb/IIIa platelet receptor for adhesive proteins result in individual differences in the thrombogenicity of platelets.

    Recent studies suggest a controversial association between a genetic polymorphism of the glycoprotein IIIa gene (PIA2) and the risk of coronary artery disease.

    In our study, the prevalence of the PIA2 allele in a group of patients undergoing percutaneous coronary revascularization was 37%, a value significantly higher than in controls [13%, odds ratio (OR)=3.93,95% CI, 1.84 to 8.53] suggesting a significant association between this polymorphism and documented coronary stenosis, which is strongest among<60 years old patients (OR=12.30,95% CI, 2.98 to 70.93).

    This polymorphism represents an inherited risk factor for severe cardiovascular disease due to coronary occlusion.

    Mots-clés Pascal : Sténose, Artère coronaire, Glycoprotéine, Membrane plasmique, Gène, Variabilité génétique, Polymorphisme, Facteur risque, Epidémiologie, Espagne, Europe, Etude cas témoin, Homme, Cardiopathie coronaire, Appareil circulatoire pathologie, Glycoprotéine IIIa

    Mots-clés Pascal anglais : Stenosis, Coronary artery, Glycoproteins, Plasma membrane, Gene, Genetic variability, Polymorphism, Risk factor, Epidemiology, Spain, Europe, Case control study, Human, Coronary heart disease, Cardiovascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0304266

    Code Inist : 002B12A03. Création : 27/11/1998.