THROMBOSIS AND HAEMOSTASIS, vol. 79, n° 6, 1998, pages 1126-1129, 25 réf., ISSN 0340-6245, DEU
GARCIA-RIBES (M.), GONZALEZ-LAMUNO (D.), HERNANDEZ-ESTEFANIA (R.), COLMAN (T.), POCOVI (M.), DELGADO-RODRIGUEZ (M.), GARCIA-FUENTES (M.), REVUELTA (J.M.)
Nutrition and Cardiovascular Risk Unit. University of Cantabria. ESP
Based on genetic variability, structural differences in the glycoprotein IIb/IIIa platelet receptor for adhesive proteins result in individual differences in the thrombogenicity of platelets.
Recent studies suggest a controversial association between a genetic polymorphism of the glycoprotein IIIa gene (PIA2) and the risk of coronary artery disease.
In our study, the prevalence of the PIA2 allele in a group of patients undergoing percutaneous coronary revascularization was 37%, a value significantly higher than in controls [13%, odds ratio (OR)=3.93,95% CI, 1.84 to 8.53] suggesting a significant association between this polymorphism and documented coronary stenosis, which is strongest among<60 years old patients (OR=12.30,95% CI, 2.98 to 70.93).
This polymorphism represents an inherited risk factor for severe cardiovascular disease due to coronary occlusion.
Mots-clés BDSP : Facteur risque, Epidémiologie, Espagne, Europe, Homme, Cardiopathie coronaire, Appareil circulatoire [pathologie]
Mots-clés Pascal : Sténose, Artère coronaire, Glycoprotéine, Membrane plasmique, Gène, Variabilité génétique, Polymorphisme, Facteur risque, Epidémiologie, Espagne, Europe, Etude cas témoin, Homme, Cardiopathie coronaire, Appareil circulatoire pathologie, Glycoprotéine IIIa
Mots-clés Pascal anglais : Stenosis, Coronary artery, Glycoproteins, Plasma membrane, Gene, Genetic variability, Polymorphism, Risk factor, Epidemiology, Spain, Europe, Case control study, Human, Coronary heart disease, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0304266
Code Inist : 002B12A03. Création : 27/11/1998.