International Scientific Valedictory Meeting in Honor of Professor T.K.A.B. Eskes. Nijmegen, NLD, 1998/04/24.
In this valedictory address the research of the Nijmegen homocysteine team on birth defects and vascular disease is presented.
Hyperhomocysteinemia was found in women with neural tube defect (NTD) offspring, other birth defects and vascular disease.
Raised homocysteine levels in the blood plasma can be explained by lack of B-vitamins (folic acid). mutation of the 5.10-methylenetetrahydrofolate reductase genes or both.
Genetic mutations were found on the first chromosome (677 C-T and 1298 A-C) and can explain up to 50% of the NTD protective effect of folic acid.
The inborn error of methionine-homocysteine metabolism was also found in cases with recurrent early pregnancy loss, schists, congenital heart defects and vascular problems like placental abruption. infarcts and fetal growth retardation.
One of the most exciting medical findings of the last years is that folic acid can prevent NTD defects.
This might also hold for other birth defects and vascular disease.
Mots-clés Pascal : Spina bifida, Homocystéine, Acide folique, Régime alimentaire enrichi, Prévention, Anencéphalie, Homme, Femelle, Gestation, Enfant, Mère, Système ostéoarticulaire pathologie, Rachis pathologie, Maladie congénitale, Malformation, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie
Mots-clés Pascal anglais : Spina bifida, Folic acid, Supplemented diet, Prevention, Anencephaly, Human, Female, Pregnancy, Child, Mother, Diseases of the osteoarticular system, Spine disease, Congenital disease, Malformation, Nervous system diseases, Central nervous system disease, Cerebral disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0302725
Code Inist : 002B17D. Création : 27/11/1998.