To determine the relative risk of hip fracture associated with postmenopausal hormone replacement therapy including the effect of duration and recency of treatment, the addition of progestins, route of administration, and dose.
Population based case-control study.
Six counties in Sweden.
1327 women aged 50-81 years with hip fracture and 3262 randomly selected controls.
Use of hormone replacement therapy.
Compared with women who had never used hormone replacement therapy, current users had an odds ratio of 0.35 (95% confidence interval 0.24 to 0.53) for hip fracture and former users had an odds ratio of 0.76 (0.57 to 1.01).
For every year of therapy, the overall risk decreased by 6% (3% to 9%) : 4% (1% to 8%) for regimens without progestin and 11% (6% to 16%) for those with progestin.
Last use between one and five years previously, with a duration of use more than five years, was associated with an odds ratio of 0.27 (0.08 to 0.94).
After five years without hormone replacement therapy the protective effect was substantially diminished (-7% to 48%). With current use, an initiation of therapy nine or more years after the menopause gave equally strong reduction in risk for hip fracture as an earlier start Oestrogen treatment with skin patches gave similar risk estimates as oral regimens. (...)
Mots-clés Pascal : Postménopause, Etude cas témoin, Randomisation, Hormone stéroïde sexuelle, Traitement substitutif, Prévention, Fracture intertrochantérienne, Fémur, Etude comparative, Evaluation, Suède, Europe, Femelle, Homme, Os, Appareil génital femelle pathologie, Ménopause, Système ostéoarticulaire pathologie, Traumatisme
Mots-clés Pascal anglais : Postmenopause, Case control study, Randomization, Sex steroid hormone, Replacement therapy, Prevention, Intertrochanteric fracture, Femur, Comparative study, Evaluation, Sweden, Europe, Female, Human, Bone, Female genital diseases, Menopause, Diseases of the osteoarticular system, Trauma
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0302570
Code Inist : 002B02O. Création : 27/11/1998.