Retrospective analysis of the impact of HIV infection and alcohol use on chronic hepatitis C in a large cohort of drug users.
This retrospective study aimed to better define the respective biological and pathological impact of human immunodeficiency virus infection and chronic alcohol consumption on the course of hepatitis C virus infection in intravenous drug users.
Two hundred and ten consecutive anti-HCV positive intravenous drug users, among whom 60 were also anti-HIV positive, took part in the study at the University Hospital, Paris, France.
The activity of aspartate aminotransferase and gamma-glutamyl transpeptidase was significantly increased in serum from anti-HIV positive patients The mean hepatitis activity index was significantly higher in anti-HIV positive patients (p<0.05), among whom there was also a higher proportion of patients with cirrhosis as compared to anti-HIV negative patients (30.0 vs 15.3%, p<0.0001).
Excessive alcohol drinking (recorded in around 35% of the patients, whatever their HIV status), as compared to non-excessive drinking, was more often associated with cirrhosis in anti-HIV negative (24.5 vs 11.3%, p<0.05) than in anti-HIV positive patients (30.4 vs 29.7%, not significant).
In a multivariate analysis, HIV infection (relative risk 2.2, confidence interval 1.1-4.5) and excessive alcohol drinking (relative risk 1.9, confidence interval 1.0-3.9) were the variables independently associated with the risk of cirrhosis. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Rétrospective, Alcoolisme, SIDA, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Corrélation, Toxicomanie, Etude cohorte, Facteur risque, France, Europe, Homme, Appareil digestif pathologie, Foie pathologie, Immunopathologie, Immunodéficit, Toxicologie, Pharmacovigilance
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Retrospective, Alcoholism, AIDS, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Correlation, Drug addiction, Cohort study, Risk factor, France, Europe, Human, Digestive diseases, Hepatic disease, Immunopathology, Immune deficiency, Toxicology, Pharmacovigilance
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0302090
Code Inist : 002B05C02G. Création : 27/11/1998.