A subacute inhalation exposure evaluation of a scrubbing solution used in petroleum refineries.
The potential for subacute toxicity and neurotoxicity of a potassium carbonate-based scrubbing solution used in petroleum refineries was evaluated in Sprague-Dawley Crl : CD BR rats.
Exposures were to aerosols of a « used » scrubbing solution by whole-body inhalation, 6 h/d, for 21 consecutive days at target concentrations of 0 (filtered air-control), 0.1,0.2, or 0.4 mg/L (30 animals/sex/group).
A functional observation battery (FOB) and locomotor activities tests were conducted and monitored.
No apparent adverse effects were noted at any exposure level as determined by clinical observations, food consumption, hematology, serum chemistry, ophthalmologic observations, and gross pathology.
Statistically significant increases in lung weights were noted at all treatment levels but returned to control values upon cessation of exposure except for the 0.4 mg/L female group.
There were no significant changes in other organ weights.
Histopathologic findings were restricted to the respiratory tract and characterized by minimal to moderate epithelial hyperplasia, epithelial necrosis, and cytoplasmic vacuolation at levels I and II of the nasal cavities.
Lung bronchiolization and alveolar macrophage infiltration were also observed.
The respiratory-tract findings were considered a local response to the high alkalinity of the test material as substantiated by the return to normal upon cessation of exposure. (...)
Mots-clés Pascal : Toxicité, Subaigu, Animal, Rat, Rodentia, Mammalia, Vertebrata, Aérosol, Potassium Carbonate, Milieu basique, Traitement hydrothermal, Inhalation, Système nerveux pathologie, Exposition professionnelle, Médecine travail
Mots-clés Pascal anglais : Toxicity, Subacute, Animal, Rat, Rodentia, Mammalia, Vertebrata, Aerosols, Potassium Carbonates, Basic medium, Hydrothermal treatment, Inhalation, Nervous system diseases, Occupational exposure, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0297733
Code Inist : 002B03L02. Création : 27/11/1998.