We performed a 5-year retrospective study to evaluate the effect of long-term administration of norfloxacin on the epidemiology of severe hospital-acquired infections in patients with advanced cirrhosis.
Sixty-seven episodes of spontaneous bacterial peritonitis and 60 episodes of bacteremia occurred in, respectively, 46 patients (group la) and 52 patients (group 1b) who did not receive norfloxacin, while 23 and 17 episodes occurred in 21 patients (group 2a) and 17 patients (group 2b) during or within 10 days after long-term administration of norfloxacin.
Enterobacteriaceae were more prevalent in groups la and 16 than in the other two groups (P<. 001 and P<. 01, respectively) ; conversely, staphylococci were more prevalent in groups 2a and 2b (P<. 001 and P<. 05, respectively).
The rate of staphylococcal resistance to methicillin was 53.6% in groups la and 1b and 77.3% in groups 2a and 2b.
We conclude that long-term norfloxacin administration to cirrhotic patients reduces the risk of gram-negative infections but increases the risk of severe hospital-acquired staphylococcal infections and of high-level resistance to antibiotics.
Mots-clés Pascal : Cirrhose, Grave, Association, Infection nosocomiale, Epidémiologie, Homme, Hôpital, Facteur risque, Traitement, Chimiothérapie, Long terme, Norfloxacine, France, Europe, Fluoroquinolone dérivé, Quinolone dérivé, Appareil digestif pathologie, Foie pathologie, Antibactérien
Mots-clés Pascal anglais : Cirrhosis, Severe, Association, Nosocomial infection, Epidemiology, Human, Hospital, Risk factor, Treatment, Chemotherapy, Long term, Norfloxacin, France, Europe, Fluoroquinolone derivatives, Quinolone derivatives, Digestive diseases, Hepatic disease, Antibacterial agent
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0297431
Code Inist : 002B13C03. Création : 27/11/1998.