To investigate prognostic factors associated with mortality in patients with psoriatic arthritis (PsA).
Patients followed up at the Toronto PsA Clinic between 1978 and 1994 were included.
Patients were reviewed at initial clinic entry and at 6-month intervals using a standard protocol.
Data on deaths were collected in a prospective manner, and death certificates were used to identify the primary and antecedent cause (s) of death.
All death information was recorded in the clinic's computerized database.
Only factors that represented standard clinical measures of isease activity and progression were studied.
The relationship between potential prognostic factors recorded at the time of the first clinic visit and the mortality rate was determined using the Cox relative risk regression model.
There were 428 patients (234 men and 194 women), of whom 68% were known to be alive on September 1,1994,20% were lost to followup but assumed to be alive, and 12% had died.
Multivariate analysis revealed that an erythrocyte sedimentation rate (ESR)>15 mm/hour, medications used prior to initial clinic visit, radiologic damage, and the absence of nail lesions were associated with an increased overall mortality rate.
There is some suggestion that prior medication use was least important for deaths associated with the circulatory system, while radiologic damage was particularly important for such deaths. (...)
Mots-clés Pascal : Rhumatisme psoriasique, Homme, Etude longitudinale, Epidémiologie, Symptomatologie, Indice gravité, Facteur prédictif, Pronostic, Mortalité, Psoriasis, Peau pathologie, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Spondylarthropathie
Mots-clés Pascal anglais : Psoriatic arthritis, Human, Follow up study, Epidemiology, Symptomatology, Severity score, Predictive factor, Prognosis, Mortality, Psoriasis, Skin disease, Diseases of the osteoarticular system, Inflammatory joint disease, Spondylarthropathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0295851
Code Inist : 002B15D. Création : 27/11/1998.