52 patients with early rheumatoid arthritis (RA) were followed with regular measurements of bone mineral density (BMD) and serum markers of type I collagen metabolism in order to determine whether they develop osteoporosis during the first two years of the disease course and if the changes in type I collagen metabolites reflect the alterations in BMD.
The mean percentage BMD change over the first year of follow-up was 0.91 for lumbar spine (LS) and - 0.76 for femoral neck (FN) ; the corresponding figures from 0 to 24 months was - 1.3 and - 0.8, respectively.
During the follow-up, only five patients developed osteoporosis by the Z-score definition (<-1).
If defined by T-score (<-2.5) none of the patients developed osteoporosis.
The BMD change correlated neither with the clinical parameters of disease activity nor with the markers of collagen metabolism.
However, the BMD change in FN was associated with the cumulative corticosteroid dose (r=-0.31, p<0.05,95% CI - 0.54 to - 0.04).
Reasons for the lack of accelerated bone loss in our series are open to various interpretations.
This series was community based and most of the patients had mild RA.
The patients were also actively treated and their physical function did not deteriorate.
Mots-clés Pascal : Polyarthrite rhumatoïde, Evolutivité, Exploration radiologique, Densité, Os, Analyse biochimique, Collagène, Remodelage osseux, Homme, Ostéopénie, Ostéoporose, Incidence, Epidémiologie, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune, Ostéopathie, Collagène type I
Mots-clés Pascal anglais : Rheumatoid arthritis, Evolutivity, Radiologic investigation, Density, Bone, Biochemical analysis, Collagen, Bone remodeling, Human, Osteopenia, Osteoporosis, Incidence, Epidemiology, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease, Bone disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0295827
Code Inist : 002B15D. Création : 27/11/1998.