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  1. Disease of the liver following bone marrow transplantation in children : Incidence, clinical course and outcome in a long-term perspective.

    Article - En anglais

    Sixty-four consecutive cases of allogeneic (n=16), autologous (n=47) or syngeneic (n=1) bone marrow transplantation (BMT) in children with haematological or lymphoid malignancy, aplasia or metabolic disease were reviewed to assess the incidence, clinical presentation and outcome of liver disease.

    Median follow-up time was 5y (1.0-10).

    No liver diagnosis was established at the pre-transplant check-up.

    During the first 100d post-transplant, 81% of the patients had impaired liver function as documented by various biochemical parameters.

    Three of 64 patients (5%) met diagnostic criteria for veno-occlusive disease.

    Four (25%) of the 16 receiving allografts were diagnosed as having acute graft vs host disease (GVHD) with liver involvement (grades II-III).

    No patient died of liver disease.

    During the late post-transplant follow-up, one patient developed HCV hepatitis after packed erythrocyte transfusion.

    Four patients were diagnosed as having chronic GVHD with liver involvement ; three of them also had an episode of CMV hepatitis.

    At their latest follow-up, the patients with chronic GVHD had aminotransferase values 1.5-3 times the normal, whereas all other long-term survivors had normal or near-normal liver function tests.

    We conclude that the incidence of serious liver disease was low in this paediatric population of bone marrow recipients.

    Mots-clés Pascal : Homotransplantation, Moelle osseuse, Complication, Foie pathologie, Incidence, Evaluation, Perspective, Long terme, Enfant, Homme, Suède, Europe, Transplantation, Chirurgie, Appareil digestif pathologie, Organisation santé

    Mots-clés Pascal anglais : Homotransplantation, Bone marrow, Complication, Hepatic disease, Incidence, Evaluation, Perspective, Long term, Child, Human, Sweden, Europe, Transplantation, Surgery, Digestive diseases, Public health organization

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0295612

    Code Inist : 002B25N. Création : 27/11/1998.