Long-term prognosis of seizures with onset in childhood.
Background The long-term prognosis of seizures that begin in childhood is uncertain.
Methods We prospectively studied 245 children from the catchment area of Turku University Hospital in Turku, Finland, who had active epilepsy diagnosed between 1961 and 1964.
Sixty-eight patients (28 percent) had idiopathic seizures (presumed to have a genetic origin), 54 (22 percent) had cryptogenic seizures (occurring in otherwise normal persons with no clear cause), and 123 (50 percent) had remote symptomatic seizures (with no immediate cause but occurring in persons with a prior brain injury or a static encephalopathy).
Results At the final follow-up in 1992, we had sufficient data on 220 patients (90 percent), 176 of whom were alive and 44 of whom had died ; the remaining 25 had emigrated, could not be traced, or declined to participate.
Thirty-nine patients who died were not free of seizures at the time of death, and 33 had remote symptomatic seizures.
Among the surviving patients, 112 (64 percent) had been seizure-free for at least five years, including 83 (47 percent) who were not taking antiepileptic medications.
The most important predictors of being seizure-free for at least five years were a rapid response to therapy (defined as a reduction in the frequency of seizures of 75 to 100 percent within three months of beginning treatment) and a diagnosis of idiopathic seizures. (...)
Mots-clés Pascal : Epilepsie, Dépistage, Prospective, Etiopathogénie, Etude longitudinale, Diagnostic, Pronostic, Enfant, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie
Mots-clés Pascal anglais : Epilepsy, Medical screening, Prospective, Etiopathogenesis, Follow up study, Diagnosis, Prognosis, Child, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0295092
Code Inist : 002B17A03. Création : 27/11/1998.