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  1. Persistent cognitive and motor deficits following acute hydrogen sulphide poisoning.

    Article - En anglais

    This case study describes the long-term after-effects of hydrogen sulphide exposure in a previously healthy 27-year-old male.

    Upon hospital admission the patient had a Glasgow Coma Score (CGS) of 3 ; with emergency treatment including hyperbaric oxygen treatments, he progressed to a GCS of 15 on day 7. Although both CT and MRI scans were unremarkable, PET using F-18 deoxyglucose administered 3 years after the accident showed abnormally decreased metabolism bilaterally in the temporal and inferior parietal lobes as well as the left thalamus.

    Uptake in the striatum was heterogeneous and abnormal.

    A cerebral perfusion study using SPECT performed 3.5 years after the accident revealed bilaterally decreased flow in the putamen but no cortical abnormalities.

    Neuropsychological and neurofunctional testing revealed the following impairments : microsmia, psychomotor slowing, extrapyramidal signs and deficits in memory and executive/planning functioning.

    These findings are discussed in the context of hydrogen sulphide's known mechanisms of toxicity and the functions of the basal ganglia.

    Mots-clés Pascal : Hydrogène Sulfure, Gaz, Tomoscintigraphie, Coma, Trouble cognition, Trouble motricité, Accident travail, Toxicité, Adulte jeune, Homme, Mâle, Etude cas, Trouble mémoire, Médecine travail, Exploration radioisotopique, Système nerveux pathologie, Trouble neurologique, Trouble conscience

    Mots-clés Pascal anglais : Hydrogen Sulfides, Gases, Emission tomography, Coma, Cognitive disorder, Motility disorder, Occupational accident, Toxicity, Young adult, Human, Male, Case study, Memory disorder, Occupational medicine, Radionuclide study, Nervous system diseases, Neurological disorder, Consciousness impairment

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0295019

    Code Inist : 002B03L02. Création : 27/11/1998.