Racial differences in the prevalence of monoclonal gammopathy in a community-based sample of the elderly.
To determine if there is an increased prevalence of monoclonal gammopathy in elderly blacks compared with whites, analogous to the difference in incidence of multiple myeloma reported for the two racial groups and to confirm age and gender relationships.
PATIENTS AND METHODS
Subjects were from the Duke Established Populations for the Epidemiologic Study of the Elderly, selected on the basis of stratified random household sampling.
Blacks were oversampled to allow for increased statistical precision in racial comparisons.
In all, 1,732 subjects (aged>70 years) consented to blood drawing and constitute the sample for this study.
Monoclonal immunoglobulins were determined by agarose gel electrophoresis and immunofixation.
One hundred six subjects (6.1%) had a monoclonal gammopathy.
There was a greater than twofold difference in prevalence between blacks (8.4%) and whites (3.8%) (P<0.001) ; monoclonal gammopathy prevalence increased with age, and was greater in men than women.
Those with monoclonal gammopathy did not differ from those without in socioeconomic status, urban/rural residence, or education.
The presence of monoclonal gammopathy was not associated with any specific diseases nor with impaired functional status.
There was a slight increase in serum creatinine levels and decrease in hemoglobin and albumin levels in patients with monoclonal gammopathy, but no difference in interleukin-6 (IL-6) levels. (...)
Mots-clés Pascal : Myélome, Multiple, Prévalence, Ethnie, Vieillard, Homme, Etude comparative, Communauté, Négroïde, Caucasoïde, Evaluation, Etats Unis, Amérique du Nord, Amérique, Hémopathie maligne, Lymphoprolifératif syndrome, Immunopathologie, Immunoglobulinopathie
Mots-clés Pascal anglais : Myeloma, Multiple, Prevalence, Ethnic group, Elderly, Human, Comparative study, Community, Negroid, Caucasoid, Evaluation, United States, North America, America, Malignant hemopathy, Lymphoproliferative syndrome, Immunopathology, Immunoglobulinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0294994
Code Inist : 002B06D02. Création : 27/11/1998.