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  1. Schizophrenia : the illness that made us human.

    Article - En anglais

    Any hypotheses concerning the origins of humans must explain many things.

    Among these are :

    • 1, the growth in brain size around two million years ago ;

    • 2, the presence of subcutaneous fat ;

    • 3, the near absence of change or cultural progress for around 2 million years after the brain grew in size ;

    • 4, the cultural explosion which began somewhere between fifty thousand and one hundred thousand years ago with the emergence of art, music, religion and warfare ;

    • 5, the further cultural explosion around ten thousand to fifteen thousand years ago which developed with the emergence of agriculture and which has continued since.

    Since the brain, like subcutaneous fat, is particularly rich in lipids, and since the microconnections of the brain are substantially lipid in nature, it is suggested that changes in lipid metabolism are what differentiated humans from the great apes.

    The growth in brain size and in the quality of subcutaneous adipose tissue may have occurred because of changes in the proteins which regulate the rate of delivery of fatty acids to tissues, notably lipoprotein lipases and fatty acid binding proteins.

    The creativity which occurred one hundred thousand years ago may have resulted from changes in phospholipid-synthesizing, - remodelling and - degrading enzymes which largely determine the microconnectivity of neurons. (...)

    Mots-clés Pascal : Schizophrénie, Hypothèse, Origine humaine, Caractéristique, Etude familiale, Protéine liaison, Acide gras, Aspect culturel, Homme, Psychose, Métabolisme pathologie, Lipide

    Mots-clés Pascal anglais : Schizophrenia, Hypothesis, Human origin, Characteristic, Family study, Binding protein, Fatty acids, Cultural aspect, Human, Psychosis, Metabolic diseases, Lipids

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0290809

    Code Inist : 002B18C06A. Création : 27/11/1998.