The aim of the study was to determine whether past exposure to hepatitis B virus (HBV) influences the risk of the development of hepatocellular carcinoma (HCC) in Japanese patients with chronic liver disease (CLD).
We conducted a hospital-based case-control study of 141 HCC patients with CLD and 151 controls with CLD but without HCC.
Past exposure to HBV was assessed by antibody to hepatitis B core antigen (anti-HBc) positivity.
Ninety-two patients (65%) with HCC were anti-HBC positive compared with 65 patients (43%) with CLD alone (P<0.01).
A multivariate analysis using logistic regression modelling revealed that anti-HBC positivity significantly increased the risk of the development of HCC [odds ratio (OR) 2.0, P=0.01]. In the anti-HBc-positive patients, a significantly increased risk of HCC was seen among the patients positive for anti-HBc alone (OR, 2.6 ; P<0.01).
However, a significant OR was not obtained among the patients with a transient HBV infection implied by positivity for both antibody to hepatitis B surface antigen and anti-HBc (OR, 1.5 ; P=0.48).
These results indicate that past exposure to HBV is a risk factor for HCC in Japanese CLD patients, especially when they have no serological evidence of immunity to HBV.
Mots-clés Pascal : Carcinome hépatocellulaire, Facteur risque, Epidémiologie, Hépatite virale B, Virose, Infection, Chronique, Japon, Asie, Etude cas témoin, Homme, Appareil digestif pathologie, Foie pathologie, Tumeur maligne
Mots-clés Pascal anglais : Hepatocellular carcinoma, Risk factor, Epidemiology, Viral hepatitis B, Viral disease, Infection, Chronic, Japan, Asia, Case control study, Human, Digestive diseases, Hepatic disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0290672
Code Inist : 002B13C01. Création : 27/11/1998.