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  1. Fulltext. Risk factors for lung cancer in young adults.

    Article - En anglais


    Risk factors for early onset of lung cancer are relatively unknown.

    In a case-control study, carried out in Germany between 1990 and 1996, the effects of smoking and familial aggregation of cancer were compared in 251 young cases and 280 young controls (<45 years) and in 2,009 older cases and 2,039 older controls (55-69 years).

    The male/female ratio was 2.6/1 in young patients and 5.6/1 in older patients.

    Adenocarcinomas were more frequent in young men than in older men (41% vs. 28%). Duration of smoking and amount smoked showed significantly increased odds ratios for lung cancer in both age groups.

    Lung cancer in a first degree relative was associated with a 2.6-fold (95% confidence interval (Cl) 1.1-6.0) increase in the risk of lung cancer in the young age group, but no elevated risk was seen in the older group (OR=1.2,95% Cl 0.9-1.6).

    Smoking-related cancer in relatives with the age at diagnosis under 46 years was associated with an increased risk of lung cancer in the young group (OR=5.6,95% Cl 0.7-46.9) but not in the older group (OR=0.7,95i6 Cl 0.3-1.5).

    Results indicated that lung cancer risk in young and older age groups shows remarkable differences with respect to sex, histologic type, and genetic predisposition.

    Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Tabagisme, Etude familiale, Epidémiologie, Facteur risque, Adulte jeune, Homme, Vieillard, Allemagne, Europe, Etude cas témoin, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie

    Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Tobacco smoking, Family study, Epidemiology, Risk factor, Young adult, Human, Elderly, Germany, Europe, Case control study, Respiratory disease, Lung disease, Bronchus disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0290596

    Code Inist : 002B11A. Création : 27/11/1998.