Risk factors for early onset of lung cancer are relatively unknown.
In a case-control study, carried out in Germany between 1990 and 1996, the effects of smoking and familial aggregation of cancer were compared in 251 young cases and 280 young controls (<45 years) and in 2,009 older cases and 2,039 older controls (55-69 years).
The male/female ratio was 2.6/1 in young patients and 5.6/1 in older patients.
Adenocarcinomas were more frequent in young men than in older men (41% vs. 28%). Duration of smoking and amount smoked showed significantly increased odds ratios for lung cancer in both age groups.
Lung cancer in a first degree relative was associated with a 2.6-fold (95% confidence interval (Cl) 1.1-6.0) increase in the risk of lung cancer in the young age group, but no elevated risk was seen in the older group (OR=1.2,95% Cl 0.9-1.6).
Smoking-related cancer in relatives with the age at diagnosis under 46 years was associated with an increased risk of lung cancer in the young group (OR=5.6,95% Cl 0.7-46.9) but not in the older group (OR=0.7,95i6 Cl 0.3-1.5).
Results indicated that lung cancer risk in young and older age groups shows remarkable differences with respect to sex, histologic type, and genetic predisposition.
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Tabagisme, Etude familiale, Epidémiologie, Facteur risque, Adulte jeune, Homme, Vieillard, Allemagne, Europe, Etude cas témoin, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Tobacco smoking, Family study, Epidemiology, Risk factor, Young adult, Human, Elderly, Germany, Europe, Case control study, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0290596
Code Inist : 002B11A. Création : 27/11/1998.