Single breath pulmonary diffusing capacity for carbon monoxide (DLco) was examined as a predictor of all-cause mortality among 4,333 subjects who were aged 25-74 years at baseline in the First National Health and Nutrition Examination Survey (NHANES I) conducted from 1971 to 1975.
The relation of the percentage of predicted DLco to all-cause mortality was examined in a Cox proportional hazard model that included age, sex, race, current smoking status, systolic blood pressure, serum cholesterol, alcohol consumption, body mass index, percentage of predicted forced vital capacity (FVC), and the ratio of forced expiratory volume at 1 second (FEV1) to FVC.
Mortality had a linear association with the percentage of predicted FVC (rate ratio (RR)=1.12,9596 confidence interval (Cl) 1.08-1.17, for a 10% decrement) and a significantly nonlinear association with the percentage of predicted DLco with an adverse effect that was clearly evident for levels below 85% of those predicted (RR=1.24,95% Cl 1.12-1.37 for a 10% decrement).
The relative hazard for the percentage of predicted DLco below 85% was not modified by sex, smoking status, or exclusion of subjects with clinical respiratory disease on the initial examination.
This association with the percentage of predicted DLco was present among 3,005 subjects with FEV1 levels above 90% of those predicted. (...)
Mots-clés Pascal : Fonction respiratoire, Spirométrie, Capacité diffusion, Poumon, Carbone monoxyde, Technique mesure, Mortalité, Epidémiologie, Prédiction, Pronostic, Adulte, Homme, Etats Unis, Amérique du Nord, Amérique, Appareil respiratoire
Mots-clés Pascal anglais : Lung function, Spirometry, Diffusing capacity, Lung, Carbon monoxide, Measurement technique, Mortality, Epidemiology, Prediction, Prognosis, Adult, Human, United States, North America, America, Respiratory system
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0290488
Code Inist : 002B30A01A2. Création : 27/11/1998.